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pentobarbital will reduce the level or influence of isavuconazonium sulfate by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.pentobarbital improves toxicity of ifosfamide by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe. CYP3A4 inducers may well raise the metabolism of ifosfamide to its Live